Products
SQLE antibody
- Product Name
- SQLE antibody
- Catalogue No.
- FNab08209
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- squalene epoxidase
- Alternative Names
- ERG1 antibody, FLJ30795 antibody, SE antibody, SM antibody, SQLE antibody, squalene epoxidase antibody, Squalene monooxygenase antibody
- UniProt ID
- Q14534
- Observed MW
- 64 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP, IF
- Recommended dilution
- WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
A549 cells were subjected to SDS PAGE followed by western blot with FNab08209(SQLE antibody) at dilution of 1:300
IP Result of anti-SQLE (IP:FNab08209, 3ug; Detection:FNab08209 1:300) with A549 cells lysate 920ug.
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab08209(SQLE Antibody) at dilution of 1:50
- Background
- SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase(HMGR, considered as rate limiting). It is also posttranslationally regulated by cholesterol-dependent proteasomal degradation.(PMID:21356516) The MW of SQLE is about 64kd.
